World number one Novak Djokovic lost to Tomas Berdych (2-6 7-5 6-4) at the Italian Open quarterfinals.
Djokovic was trying to grab his third Rome title but has been troubled by pain in his ankle.
World number six Berdych had already lost twice to Djokovic this year. His only victory against the Serbian came in the 2010 Wimbledon semi-finals.
Spain’s Rafael Nadal, on the other hand, stayed on track for his third straight title. He beat fellow Spaniard David Ferrer in 6-4 4-6 6-2 victory. Frenchman Benoit Paire also advanced.
The French reached the first Masters Series semi-final of his career with a victory over Spaniard Marcel Granollers. He will now face Roger Federer for a place in the Rome finals.
Federer beat rising Polish player Jerzy Janowicz with a 6-4 7-6 (7-2) victory.